The following diagnostic criteria for aHUS have been agreed by the aHUS Rare Disease Group:
Inclusion
- Renal biopsy showing a thrombotic microangiopathy
and/or
- Triad of microangiopathic haemolytic anaemia, thrombocytopenia and renal failure
Exclusion
- Thrombotic thrombocytopenic purpura
- Shiga toxin associated HUS
- Drug mediated TMA
- Infection (HIV, Streptococcus pneumonia)
- Transplantation (bone marrow, liver, lung, cardiac)
- Cobalamin deficiency
- Systemic lupus erythematosis
- Antiphospholipid antibody syndrome
- Scleroderma