Laboratory Diagnostics for C3G

Laboratory Diagnostics for C3G


We have established a combined lab diagnostics service in Newcastle upon Tyne Hospitals that encompasses genetic and immunological evaluation of the complement system that may be useful in the investigation of C3G.


Testing performed at combined lab diagnostic services

Serological testing

  • C3, C4, C3 nephritic factor, FH, FI,
  • FH autoantibodies

Genetic testing

  •  Coding exons of CFH, CFI, CD46, C3, CFB, DGKE
  • Copy number of CFH, CFI, CD46, CFHR1, CFHR3 and CFHR5

These tests can be requested using the form available from the Northern Molecular Genetics Service here

Some additional testing eg FB and sC5b-9 may be helpful and can be requested following discussion with a consultant at the NRCTC.