C3 Glomerulonephritis

C3 Glomerulonephritis

 

C3 glomerulonephritis (C3GN) is a form of C3G in which the dense osmiophilic intramembranous deposits that define DDD are not identified on electron microscopy. Appearances on EM include light dense, amorphous mesangial, paramesangial, sub-endothelial and sub-epithelial deposits.

 

The IF criterion used to classify C3G captures the majority of cases of C3GN. Light microscopy identifies a diverse pattern of glomerular injury that includes MPGN, mesangial hypercellularity and proliferative glomerulonephritis.